Isopropanol Vapor Inhalation Oncogenicity Study in Fischer 344 Rats and CD-1 Mice
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منابع مشابه
Methyl isocyanate eight-day vapor inhalation study with Fischer 344 rats.
Groups of ten male and ten female Fischer 344 rats were exposed by inhalation 3.1, 0.6, 0.15, or 0.0 (control) ppm of methyl isocyanate (MIC) vapor 6 hr per day for 8 days (two 4-day sessions separated by a 2-day rest). Evaluation of toxic effects included body weight, food consumption, organ weights, and selected hematologic, ophthalmic, neurologic, gross anatomic, and histologic examinations....
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The retention, distribution, metabolism, and excretion of [C]octamethylcyclotetrasiloxane (D4) were studied in Fischer 344 rats after single and multiple exposures to 7, 70, or 700 ppm [C]D4. Subset groups were established for body burden, distribution, and elimination. Retention of inhaled D4 was relatively low (5–6% of inhaled D4). Radioactivity derived from [ C]D4 inhalation was widely distr...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 1997
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/36.2.95